Wafik El-Deiry: Unraveling Cancer Plasticity and Histological Transformation in Precision Oncology
Wafik S. El-Deiry/LinkedIn Wafik El-Deiry, Mencoff Family University Professor of Medical Science and Professor of Pathology and Laboratory Medicine at Brown University, shared...
Wafik S. El-Deiry/LinkedIn Wafik El-Deiry , Mencoff Family University Professor of Medical Science and Professor of Pathology and Laboratory Medicine at Brown University, shared on LinkedIn : “Pleased to share review publication by Nick Kuburich , and colleagues including Petra den Hollander, Yakirevich Evgeny, Razelle Kurzrock, Sendurai Mani, and Vivek Subbiah.
Cancer plasticity and histological transformation as adaptive resistance mechanisms in precision oncology.” Title: Cancer plasticity and histological transformation as adaptive resistance mechanisms in precision oncology Authors : Nick A Kuburich, Mohamed A Gouda, Breanna R Demestichas, Preetesh Jain, Petra den Hollander, Evgeny Yakirevich, Razelle Kurzrock, Wafik S El-Deiry, Sendurai A Mani, Vivek Subbiah.
The advent of precision oncology has brought substantial advancements in cancer therapy, yet it has been accompanied by equally complex resistance mechanisms. Among these mechanisms, histological transformations can compromise the effectiveness of targeted therapies, resulting in a loss of clinical benefit following initial success.
Understanding these evolutionary processes is crucial for developing the next generation of cancer treatments that can effectively combat resistance. This review examines histological transformation as a key mechanism of resistance to anticancer therapies , driven by various forms of tumor plasticity, and explores into the underlying processes and mechanisms that drive these changes.
We also discuss how precision oncology and an appreciation of cancer plasticity can be leveraged to overcome histological transformation and lead to improved patient outcomes. Read the full article. You may also be interested in : Wafik El-Deiry: Exploring N-of-1 Precision Oncology With Razelle Kurzrock Stay Informed Subscribe to OncoDaily Newsletter Don't miss the latest news in oncology: stay up to date with daily picks from OncoDaily.
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